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Coralyne (chloride)

CAT: 0804-HY-118581-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118581-01Size:5 mg
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Description
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes[3].
CAS Number
38989-38-7
Product Name Alternative
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
UNSPSC
12352005
Hazard Statement
H301, H413
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/coralyne-chloride.html
Purity
98.30
Solubility
DMSO : 1.82 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C2C=C(C(OC)=CC2=CC3=C4C=C(C(OC)=CC4=CC=[N+]13)OC)OC.[Cl-]
Molecular Formula
C22H22ClNO4
Molecular Weight
399.87
Precautions
H301, H413
References & Citations
[1]Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445.|[2]D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4 (6) :781-91.|[3]P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7 (18) :10660-10667.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I

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