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RU.521

CAT: 0804-HY-114180-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114180-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) [1].
CAS Number
2262452-06-0
Product Name Alternative
RU320521
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ru-521.html
Purity
99.95
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
Molecular Formula
C19H12Cl2N4O3
Molecular Weight
415.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8 (1) :750.|[2]Xu Q, et al. Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice. Life Sci. 2020 Nov 1;260:118315.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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