Gap 26 (TFA)

• Description:

  Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif[1].

• UNSPSC:

  12352209

• Target:

  Connexin; Gap Junction Protein

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/gap-26-tfa.html

• Purity:

  99.68

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

• Smiles:

  OC(C(F)(F)F)=O.O=C(N[C@@H](CS)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

• Molecular Formula:

  C72H108F3N19O21S

• Molecular Weight:

  1664.80

• References & Citations:

  [1]Katleen Braet, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33 (1) :37-48.|[2]Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 (Pt 1) :99-110.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Citation 01:

  Cureus. 2024 Apr 26;16 (4) :e59053.|ACS Chem Biol. 2020 Jun 19;15 (6) :1392-1400.|Biomed Pharmacother. 2022 Apr 22;150:112973.|Cell Metab. 2021 Feb 2;33 (2) :283-299.e9.|J Immunol. 2025 Jan 1;214 (1) :130-140.|Lab Invest. 2022 Jan;102 (1) :90-101.|Medicina (Kaunas) . 2024 May 8;60 (5) :780.|Toxicology. 2022 Aug:478:153283.