BC11-38

• Description :

  BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/bc11-38.html

• Purity :

  99.42

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(CCS2)N=C(SCCC)N1C3=CC=CC=C3

• Molecular Formula :

  C15H16N2OS2

• Molecular Weight :

  304.43

• References & Citations :

  [1]Ceyhan O, et al. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19 (1) :155-163.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE10; PDE11

• CAS Number :

  [686770-80-9]