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Pro-PEG3-BA

CAT: 0013-GTR19277082-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277082-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pro-PEG3-BA is a PROTAC degrader targeting EML4-ALK and EGFR, effectively degrading EML4-ALK and EGFR mutants (L858R/T790M) with DC50 values of 0.42 μM and 13.50 μM, respectively. In vitro, it inhibits the proliferation of non-small cell lung cancer cells, inducing cell cycle arrest and apoptosis. Pro-PEG3-BA demonstrates favorable safety characteristics and can reduce EML4-ALK protein expression by modulating the ubiquitin-proteasome system in vivo, making it suitable for research on non-small cell lung cancer.
CAS Number
3057939-64-4
Smiles
O (C) C=1C=C (C=CC1NC=2N=C (NC3=C (P (C) (C) =O) C=CC=C3) C (Cl) =CN2) N4CCN (C (CCOCCOCCOCCNC (=O) [C@@H]5CCCN5) =O) CC4
Molecular Formula
C37H52ClN8O7P
Molecular Weight
787.3
Storage Conditions
-20°C
Notes
For research use only.

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