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Lavendustin A

CAT: 0804-HY-18963-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18963-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis[1][2].
CAS Number
125697-92-9
Product Name Alternative
RG-14355
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Lavendustin_A.html
Concentration
10mM
Purity
98.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(N(CC2=CC(O)=CC=C2O)CC3=CC=CC=C3O)=CC=C1O
Molecular Formula
C21H19NO6
Molecular Weight
381.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Onoda T, et, al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52 (6) :1252-7. |[2]Hu DE, et, al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114 (2) :262-8. |[3]Whitehead SA, et, al. Protein tyrosine kinase activity of lavendustin A and the phytoestrogen genistein on progesterone synthesis in cultured rat ovarian cells. Fertil Steril. 2000 Mar;73 (3) :613-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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