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BW-AQ-113

CAT: 0013-GTR19274999-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274999-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BW-AQ-113 is a derivative of Anthraquinone that specifically degrades MDM2 and activates the p53 pathway. It exhibits IC50 values of 0.12 μM in Molt-4 cells and 0.2 μM in EU-1 cells. In p53-deficient K562 cells, p53-mutant T98G cells, and p53-inhibited HeLa cells, its IC50 values are 0.74, 5.2, and 2.1 μM, respectively. BW-AQ-113 induces apoptosis by downregulating the anti-apoptotic gene Bcl-2 and upregulating pro-apoptotic genes Bax and CASP3. Additionally, BW-AQ-113 can be utilized in research on hematologic malignancies with wild-type p53.
CAS Number
1537900-10-9
Smiles
O=C1C=2C=CC=C (OCC) C2C (=O) C3=C (OCC) C=C (C=C13) NC (=O) CCl
Molecular Formula
C20H18ClNO5
Molecular Weight
387.82
Storage Conditions
-20°C
Notes
For research use only.

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