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Axl-IN-21

CAT: 0013-GTR19274450-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274450-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Axl-IN-21 is an orally bioavailable selective AXL inhibitor with a Kd of 2.7 nM and an IC50 of 4.0 nM. It demonstrates strong inhibitory activity against various cancer-related kinases while maintaining kinase selectivity, including Mer (Kd = 1.4 nM), DDR1 (IC50 = 22.2 nM), HIPK4 (Kd = 11.0 nM), and LOK (Kd = 10 nM) . By blocking the AXL/STAT3/ABCG1 signaling pathway induced by GAS6 from tumor-associated fibroblasts, Axl-IN-21 can overcome tumor microenvironment-driven resistance, restore chemotherapy sensitivity, and inhibit drug efflux. In MDA-MB-231 cells, it inhibits TGF-β1-induced epithelial-mesenchymal transition, cell migration, and invasion. Axl-IN-21 exhibits no significant toxicity to non-cancer cells and is relevant for research in triple-negative breast cancer and gastric cancer.
CAS Number
1958081-87-2
Smiles
O=C (NC1=CC=C (OC2=NC=NC=3C=C (OC) C (OC) =CC23) C (F) =C1) C=4C (=O) C5=CC (=CC=C5N (C4C) C) CC
Molecular Formula
C30H27FN4O5
Molecular Weight
542.57
Storage Conditions
-20°C
Notes
For research use only.

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