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AXL-IN-13

CAT: 0013-GTR19212234-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212234-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AXL-IN-13 is a potent, orally bioavailable small molecule inhibitor of AXL kinase, demonstrating high affinity with a Kd of 0.26 nM. It exhibits anticancer activity by reversing TGF-β1-induced epithelial-mesenchymal transition (EMT), thereby inhibiting cancer cell migration and invasion in vitro, and shows potential for in vivo tumor growth suppression studies.
CAS Number
2376928-82-2
Product Name Alternative
FLT3, PDGFR, AXL, Smad, TGFb, TGF-b/Smad, TGFβ1, TGF-β/Smad, TGFβ, TGFbeta, TGF-beta, TGFbeta/Smad, TAMReceptor, TAM Receptor
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.20% (May vary between batches)
Solubility
DMSO:6.33 mg/mL (10 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.58 mM)
Smiles
O (C=1C2=C (C=C (OCCCN3CCOCC3) C (OC) =C2) N=CC1) C4=C (F) C=C (NC=5C (C (NC6CCCCC6) =O) =CN (C) N5) C=C4
Molecular Formula
C34H41FN6O5
Molecular Weight
632.72
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

CatalogName
BA8966-100AXL-IN-13
CSB-CL326981HUAXL
ABC-X0245CXpressTM Human AXL Over-expressing Cell Line (MOLM-13)
209692-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) discontinued
MBS6407952-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (Biotin)
MBS6407953-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (FITC)
MBS6407951-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (APC)
MBS6407960-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (PE)
MBS6407954-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (HRP)
MBS6407950-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (AP)

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