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TRF1-TIN2 interaction-IN-1

CAT: 0013-GTR19258534-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258534-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM) . By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.
Field of Research
Molecular Biology
Smiles
OS (C1=CC=C (OCC2=CC (OC) =CC (OC) =C2) C3=C1C=CC=C3) (=O) =O
Molecular Formula
C19H18O6S
Molecular Weight
374.41
Storage Conditions
-20°C
Notes
For research use only.

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