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TDPAM01

CAT: 0013-GTR19274281-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274281-01Size:10 mg
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Description
TDPAM01 acts as a positive allosteric modulator of the AMPA receptor GluA2. It specifically binds to the ligand-binding domain (LBD) of GluA2, with an IC50 value of 13.4 nM for the GluA2 flop subtype. TDPAM01 stabilizes the active conformation of the GluA2 receptor, delaying receptor inactivation or desensitization, thereby sustaining rapid excitatory synaptic transmission in the central nervous system.
CAS Number
2231103-08-3
Smiles
O=S1 (=O) NCN (C2=CC (=CC=C21) CCC3=CC=C4C (=C3) N (C) CNS4 (=O) =O) C
Molecular Formula
C18H22N4O4S2
Molecular Weight
422.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide)
CAS Number2231103-08-3
PubChem CID134828072
IUPAC Name4-methyl-6-[2-(4-methyl-1,1-dioxo-2,3-dihydro-1lambda6,2,4-benzothiadiazin-6-yl)ethyl]-2,3-dihydro-1lambda6,2,4-benzothiadiazine 1,1-dioxide
Molecular FormulaC18H22N4O4S2
Molecular Weight422.5
XLogP2.1
Topological Polar Surface Area116
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity710
SMILES
CN1CNS(=O)(=O)C2=C1C=C(C=C2)CCC3=CC4=C(C=C3)S(=O)(=O)NCN4C
InChI
InChI=1S/C18H22N4O4S2/c1-21-11-19-27(23,24)17-7-5-13(9-15(17)21)3-4-14-6-8-18-16(10-14)22(2)12-20-28(18,25)26/h5-10,19-20H,3-4,11-12H2,1-2H3
InChIKey
PZUOXMWBXQXKJK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide)
CAS: 2231103-08-3
CID: 134828072
Formula: C18H22N4O4S2
MW: 422.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight422.5
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass422.10824754
Monoisotopic Mass422.10824754
Topological Polar Surface Area116 Ų
Heavy Atom Count28
Formal Charge0
Complexity710
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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