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VX-148

CAT: 0013-GTR19241618-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241618-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VX-148 is a potent and selective non-competitive inhibitor of IMPDH Type II (Ki=6 nM), showing superior anti-proliferative activity in human lymphocytes (IC50 ~80 nM) compared to mycophenolic acid. Its in vivo efficacy is demonstrated by dose-dependent immunosuppression and prolonged skin graft survival in murine models, with effects reversible by guanosine.
CAS Number
297730-05-3
Smiles
N (C (NC1=CC ([C@@H] (NC (O[C@@H] (CC#N) CC) =O) C) =CC=C1) =O) C2=CC (OC) =C (C#N) C=C2
Molecular Formula
C23H25N5O4
Molecular Weight
435.48
Storage Conditions
-20°C
Notes
For research use only.

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