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AGU661

CAT: 0013-GTR19273262-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273262-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGU661 is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) with an IC50 of 0.22 nM. It effectively reduces PGE2 production in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. Despite its poor physicochemical properties, low metabolic stability, and high plasma protein binding rate, encapsulating AGU661 in PLGA-based nanoparticles significantly enhances its bioactivity. AGU661 is applicable for research on inflammatory diseases.
CAS Number
3038861-75-2
Smiles
O=C (NC=1C=CC (=CC1) C2=NC3=CC=C (C=C3N2) C (F) (F) F) C4=CC (=CC=C4Cl) CNC (=O) C5 (CCC5) C (F) (F) F
Molecular Formula
C28H21ClF6N4O2
Molecular Weight
594.94
Storage Conditions
-20°C
Notes
For research use only.

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