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AGU661

CAT: 0804-HY-178794Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178794Size:1 Each
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Description
AGU661 is a Microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitor with an IC50 of 0.22 nM. AGU661 lowers PGE2 formation in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. AGU661 has unfavorable physicochemical properties with poor metabolic stability and strong plasma protein binding tendencies. AGU661 into PLGA-based NPs significantly enhances its bioactivity. AGU661 can be used for inflammatory disorders research[1].
CAS Number
3038861-75-2
UNSPSC
12352005
Target
PGE synthase
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
ClC(C=CC(CNC(C1(CCC1)C(F)(F)F)=O)=C2)=C2C(NC(C=C3)=CC=C3C4=NC5=CC(C(F)(F)F)=CC=C5N4)=O
Molecular Formula
C28H21ClF6N4O2
Molecular Weight
594.94
References & Citations
[1]Dahlke P, et al. Enhanced Efficiency of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AGU661 in Human Whole Blood by Encapsulation into PLGA-Based Nanoparticles. Mol Pharm. 2025 Nov 3;22 (11) :6803-6815.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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