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EGFR-IN-176

CAT: 0013-GTR19273260-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273260-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-176 is an orally active and ATP-competitive inhibitor specifically targeting mutated forms of EGFR, particularly the C797S-mediated EGFR triple mutant. It effectively inhibits the activation of the AKT signaling pathway and induces apoptosis in Ba/F3 and PC-9 cells, which express EGFR19del/T790M/C797S or EGFRL858R/T790M/C797S mutations, respectively. EGFR-IN-176 selectively blocks EGFR signaling in cell lines with the EGFR triple mutation, without affecting wild-type EGFR expressed in A431 cells. Additionally, EGFR-IN-176 effectively inhibits ALK enzyme activity with an IC50 of less than 0.5 nM and is useful in the study of non-small cell lung cancer.
CAS Number
2754394-10-8
Smiles
O=S (=O) (N (C1=C2N=CC=NC2=CC=C1NC=3N=C (N=C4NC=CC43) NC=5C=C (C (=CC5OC) N6CCC (N7CCN (C) CC7) CC6) CC) C) C
Molecular Formula
C35H45N11O3S
Molecular Weight
699.88
Storage Conditions
-20°C
Notes
For research use only.

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