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KOR agonist 7

CAT: 0013-GTR19274157-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274157-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KOR agonist 7 (Compound 29) is a highly selective κ-opioid receptor (KOR) agonist with a Ki of 138 nM. It shows no activity on μ and δ opioid receptors or the σ1 receptor, and exhibits very low affinity for the σ2 receptor (Ki = 2.8 μM) . This compound significantly reduces the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, and IFN-γ, while increasing the secretion of the anti-inflammatory cytokine IL-10. Additionally, KOR agonist 7 decreases the expression of pro-inflammatory M1 macrophage marker (CD80) and increases the expression of anti-inflammatory M2 macrophage marker (CD163) . It can be utilized for pain relief and immunomodulation.
Storage Conditions
-20°C
Notes
For research use only.

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