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Flavokawain 1i

CAT: 0931-T83890-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83890-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1098176-51-2
Target
Others, HSP
Related Pathways
Others, Cytoskeletal Signaling, Metabolism
Bioactivity
Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties. At a concentration of 30 μM, it suppresses the growth of gefitinib-resistant H1975 non-small cell lung cancer (NSCLC) cells by 36% and modulates the protein expression by reducing the levels of heat shock protein 90 (Hsp90) client proteins, including EGFR, c-Met, HER2, Akt, and cyclin-dependent kinase 4 (Cdk4), while increasing the levels of Hsp70, indicative of Hsp90 inhibition. Additionally, intramuscular injection of flavokawain 1i lowers viral loads in pigs afflicted with porcine reproductive and respiratory syndrome virus (PRRSV) .
Smiles
COC1=C(C(O)=CC(OC)=C1)C(/C=C/C2=C3C(C=CC=C3)=CC=C2)=O
Molecular Formula
C21H18O4
Molecular Weight
334.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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