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SHP2-IN-44

CAT: 0013-GTR19273071-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273071-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP2-IN-44 (Compound 26) is an allosteric, orally active inhibitor of SHP2, with an IC50 of 27 nM. It effectively inhibits ERK phosphorylation with an IC50 of 299 nM and exhibits no off-target hERG activity. SHP2-IN-44 shows broad-spectrum anticancer activity, including efficacy against juvenile myelomonocytic leukemia, neuroblastoma, and breast cancer. It is also useful for research in Noonan syndrome, LEOPARD syndrome, and cancer.
CAS Number
2818955-47-2
Smiles
C (N) [C@]1 ([C@@]2 ([C@]1 (CCN (C2) C3=NC (N) =C (SC=4C (Cl) =C (N) N=CC4) N=C3) [H]) [H]) C5=C (F) C=CC=C5
Molecular Formula
C22H23ClFN7S
Molecular Weight
471.98
Storage Conditions
-20°C
Notes
For research use only.

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