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H3R antagonist 8

CAT: 0013-GTR19272923-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272923-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H3R antagonist 8 is a selective non-imidazole histamine H3 receptor antagonist (IC50= 0.35 μM) that also exhibits hERG channel blocking activity (IC50= 0.67 μM) . It suppresses seizures by antagonizing the H3 receptor and reduces tonic hindlimb extension (THLE) in mice in the maximal electroshock seizure (MES) model (ED50= 20.21 mg/kg) . Additionally, it shortens the total movement distance induced by pentylenetetrazol (PTZ) in AB strain zebrafish larvae. H3R antagonist 8 is applicable in epilepsy research.
CAS Number
3097193-89-7
Smiles
ClC=1C=CC=CC1C=2OC (=NC2C3=CC=C (OCCCN (CC) CC) C=C3) C
Molecular Formula
C23H27ClN2O2
Molecular Weight
398.93
Storage Conditions
-20°C
Notes
For research use only.

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