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H3R antagonist 4

CAT: 0013-GTR19238980-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238980-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This research compound, H3R antagonist 4 (11l), is a potent dual-acting agent targeting Alzheimer's disease pathology. It reversibly inhibits cholinesterases (IC50: 7.04 μM eeAChE, 9.73 μM hAChE) and histamine H3 receptors (1.09 nM), while also disrupting Aβ aggregation, chelating biometals, and reducing tau hyperphosphorylation. Demonstrated in vitro and in vivo, it shows neuroprotective effects against apoptosis/ferroptosis and improves cognitive deficits in scopolamine-induced mouse models.
Field of Research
Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C30H36N2O9
Molecular Weight
568.61
Storage Conditions
-20°C
Notes
For research use only.

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