Products for Research Use Only
RegisterLogin

LIQ1

CAT: 0013-GTR19274464-02Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19274464-02Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LIQ1 is a flavonoid derivative and a potent allosteric inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.39 μM and a Kd of 4.5 μM, targeting the Arg43 in the poly-arginine pocket. It demonstrates efficacy in an LPS-induced mouse endotoxemia model by preventing PKM2 nuclear translocation and inhibiting its interaction with HIF-1α, thus suppressing IL-1β transcription. LIQ1 is applicable in endotoxemia research.
CAS Number
2606032-80-6
Smiles
O=C (O) C=1C=CC=CC1C2OC3=CC (O) =CC=C3C (=O) C2
Molecular Formula
C16H12O5
Molecular Weight
284.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-(7-Hydroxy-4-oxo-2,3-dihydrochromen-2-yl)benzoic acid
CAS Number2606032-80-6
PubChem CID178421149
IUPAC Name2-(7-hydroxy-4-oxo-2,3-dihydrochromen-2-yl)benzoic acid
Molecular FormulaC16H12O5
Molecular Weight284.26
XLogP2.1
Topological Polar Surface Area83.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity421
SMILES
C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=CC=C3C(=O)O
InChI
InChI=1S/C16H12O5/c17-9-5-6-12-13(18)8-15(21-14(12)7-9)10-3-1-2-4-11(10)16(19)20/h1-7,15,17H,8H2,(H,19,20)
InChIKey
CRQAOKDMEJPZTH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(7-Hydroxy-4-oxo-2,3-dihydrochromen-2-yl)benzoic acid
CAS: 2606032-80-6
CID: 178421149
Formula: C16H12O5
MW: 284.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight284.26
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass284.06847348
Monoisotopic Mass284.06847348
Topological Polar Surface Area83.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity421
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-179371LIQ1

Popular Products