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LIQ1

CAT: 0013-GTR19274464-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274464-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIQ1 is a flavonoid derivative and a potent allosteric inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.39 μM and a Kd of 4.5 μM, targeting the Arg43 in the poly-arginine pocket. It demonstrates efficacy in an LPS-induced mouse endotoxemia model by preventing PKM2 nuclear translocation and inhibiting its interaction with HIF-1α, thus suppressing IL-1β transcription. LIQ1 is applicable in endotoxemia research.
CAS Number
2606032-80-6
Smiles
O=C (O) C=1C=CC=CC1C2OC3=CC (O) =CC=C3C (=O) C2
Molecular Formula
C16H12O5
Molecular Weight
284.27
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-179371LIQ1

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