DSPE-PEG4-DBCO

• Description:

  DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dspe-peg4-dbco.html

• Purity:

  95.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N1C2=CC=CC=C2C#CC3=CC=CC=C3C1) CCNC (CCOCCOCCOCCOCCC (NCCOP (OC[C@H] (OC (CCCCCCCCCCCCCCCCC) =O) COC (CCCCCCCCCCCCCCCCC) =O) (O) =O) =O) =O

• Molecular Formula:

  C71H116N3O15P

• Molecular Weight:

  1282.67

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PEG Linkers

• CAS Number:

  2112738-14-2