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TGP-377

CAT: 0013-GTR19264590-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264590-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGP-377 is a potent inhibitor of miR-377 that specifically and effectively enhances the expression of VEGFA by targeting the non-coding microRNA that regulates VEGFA expression.
CAS Number
2665700-67-2
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction
Smiles
O=C (N) CN (C (=O) CN (C (=O) CN (C (=O) CN (C (=O) CN (C (=O) CCCOC1=CC (=CC (=C1) C2=NC=3C=CC (N) =CC3N2) C4=NC5=CC=C (N) C=C5N4) CCC) CCC) CCC) CCC) CCCN6N=NC (=C6) CN7CCN (C=8N=C (N=C (C8) NC9=NC=CC (=C9) NC=%10N=C%11C=CC=CC%11=CC%10) C) CC7
Molecular Formula
C75H93N23O7
Molecular Weight
1428.69
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[2-[[2-[[2-[[2-[(2-amino-2-oxoethyl)-[3-[4-[[4-[2-methyl-6-[[4-(quinolin-2-ylamino)-2-pyridinyl]amino]pyrimidin-4-yl]piperazin-1-yl]methyl]triazol-1-yl]propyl]amino]-2-oxoethyl]-propylamino]-2-oxoethyl]-propylamino]-2-oxoethyl]-propylamino]-2-oxoethyl]-4-[3,5-bis(6-amino-1H-benzimidazol-2-yl)phenoxy]-N-propylbutanamide
CAS Number2665700-67-2
PubChem CID178203446
IUPAC NameN-[2-[[2-[[2-[[2-[(2-amino-2-oxoethyl)-[3-[4-[[4-[2-methyl-6-[[4-(quinolin-2-ylamino)-2-pyridinyl]amino]pyrimidin-4-yl]piperazin-1-yl]methyl]triazol-1-yl]propyl]amino]-2-oxoethyl]-propylamino]-2-oxoethyl]-propylamino]-2-oxoethyl]-propylamino]-2-oxoethyl]-4-[3,5-bis(6-amino-1H-benzimidazol-2-yl)phenoxy]-N-propylbutanamide
Molecular FormulaC75H93N23O7
Molecular Weight1428.7
XLogP6.9
Topological Polar Surface Area376
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count21
Rotatable Bond Count36
Heavy Atom Count105
Formal Charge0
Complexity2680
SMILES
CCCN(CC(=O)N(CCC)CC(=O)N(CCC)CC(=O)N(CCC)CC(=O)N(CCCN1C=C(N=N1)CN2CCN(CC2)C3=NC(=NC(=C3)NC4=NC=CC(=C4)NC5=NC6=CC=CC=C6C=C5)C)CC(=O)N)C(=O)CCCOC7=CC(=CC(=C7)C8=NC9=C(N8)C=C(C=C9)N)C1=NC2=C(N1)C=C(C=C2)N
InChI
InChI=1S/C75H93N23O7/c1-6-25-93(69(100)16-12-35-105-58-37-52(74-84-60-20-18-54(76)39-62(60)86-74)36-53(38-58)75-85-61-21-19-55(77)40-63(61)87-75)46-70(101)94(26-7-2)47-71(102)95(27-8-3)48-72(103)96(28-9-4)49-73(104)97(45-64(78)99)29-13-30-98-44-57(89-90-98)43-91-31-33-92(34-32-91)68-42-67(80-50(5)81-68)88-66-41-56(23-24-79-66)82-65-22-17-51-14-10-11-15-59(51)83-65/h10-11,14-15,17-24,36-42,44H,6-9,12-13,16,25-35,43,45-49,76-77H2,1-5H3,(H2,78,99)(H,84,86)(H,85,87)(H2,79,80,81,82,83,88)
InChIKey
JFZKAFCGOWHIRV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[2-[[2-[[2-[[2-[(2-amino-2-oxoethyl)-[3-[4-[[4-[2-methyl-6-[[4-(quinolin-2-ylamino)-2-pyridinyl]amino]pyrimidin-4-yl]piperazin-1-yl]methyl]triazol-1-yl]propyl]amino]-2-oxoethyl]-propylamino]-2-oxoethyl]-propylamino]-2-oxoethyl]-propylamino]-2-oxoethyl]-4-[3,5-bis(6-amino-1H-benzimidazol-2-yl)phenoxy]-N-propylbutanamide
CAS: 2665700-67-2
CID: 178203446
Formula: C75H93N23O7
MW: 1428.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1428.7
XLogP36.9
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count21
Rotatable Bond Count36
Exact Mass1427.76283240
Monoisotopic Mass1427.76283240
Topological Polar Surface Area376 Ų
Heavy Atom Count105
Formal Charge0
Complexity2680
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-176805TGP-377
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