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Enpp-1-IN-27

CAT: 0013-GTR19265390-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19265390-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.
Field of Research
Immunology & Inflammation, Metabolism Research
Storage Conditions
-20°C
Notes
For research use only.

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