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PBD dimer-4

CAT: 0013-GTR19263881-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263881-01Size:25 mg
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Description
PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM) . PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.
CAS Number
1821339-88-1
Field of Research
Molecular Biology
Smiles
O (CCCO[C@@H]1[C@@]2 (N (CC1) C (=O) C=3C (N=C2) =CC (OC) =C (OC) C3) [H]) [C@@H]4[C@@]5 (N (C (=O) C=6C (N=C5) =CC (OC) =C (OC) C6) CC4) [H]
Molecular Formula
C31H36N4O8
Molecular Weight
592.64
Storage Conditions
-20°C
Notes
For research use only.

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