Products for Research Use Only

MARY1

CAT: 0013-GTR19263756-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263756-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MARY1 is a selective 5-HT2BR antagonist with an IC50 of 380 nM and a Ki of 764 nM [human 5-HT2BR]. It promotes mitochondrial biogenesis (MB) in the kidneys and enhances mitochondrial function by increasing mitochondrial respiration capacity, protein levels, and number in renal proximal tubular cells (RPTC) . MARY1 induces MB in RPTCs through the 5-HT2BR and dual PI3K/AKT and RAS/MEK/ERK signaling pathways. It is useful for studying kidney diseases related to metabolic and mitochondrial dysfunction.
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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CatalogName
HY-174306MARY1

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