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MARY1

CAT: 0931-T211361-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211361-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
5-HT Receptor, Akt, Ras, ERK, MEK, PI3K
Related Pathways
Metabolism, PI3K/Akt/mTOR signaling, GPCR/G Protein, MAPK, Neuroscience, Cytoskeletal Signaling
Bioactivity
MARY1 is a selective 5-HT2BR antagonist with an IC50 of 380 nM and a Ki of 764 nM [human 5-HT2BR]. It promotes mitochondrial biogenesis (MB) in the kidneys and enhances mitochondrial function by increasing mitochondrial respiration capacity, protein levels, and number in renal proximal tubular cells (RPTC) . MARY1 induces MB in RPTCs through the 5-HT2BR and dual PI3K/AKT and RAS/MEK/ERK signaling pathways. It is useful for studying kidney diseases related to metabolic and mitochondrial dysfunction.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CatalogName
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