MARY1

CAT: 0931-MF-0118499-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118499-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
5-HT Receptor|||Akt|||Ras|||ERK|||MEK|||PI3K
Related Pathways
Metabolism|||PI3K/Akt/mTOR signaling|||GPCR/G Protein|||MAPK|||Neuroscience|||Cytoskeletal Signaling
Bioactivity
MARY1 is a selective 5-HT2BR antagonist with an IC50 of 380 nM and a Ki of 764 nM [human 5-HT2BR]. It promotes mitochondrial biogenesis (MB) in the kidneys and enhances mitochondrial function by increasing mitochondrial respiration capacity, protein levels, and number in renal proximal tubular cells (RPTC) . MARY1 induces MB in RPTCs through the 5-HT2BR and dual PI3K/AKT and RAS/MEK/ERK signaling pathways. It is useful for studying kidney diseases related to metabolic and mitochondrial dysfunction.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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