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STING-IN-16

CAT: 0013-GTR19263728-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263728-01Size:50 mg
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Description
STING-IN-16 is an inhibitor of STING, with an IC50 value of 44 nM in humans and 32 nM in mice. This compound effectively suppresses the activation of the STING pathway in both human and mouse cells. STING-IN-16 aids in restoring kidney mitochondrial function, inhibits the production of reactive oxygen species (ROS), and reduces apoptosis. It exhibits significant anti-inflammatory effects in vivo and is a valuable tool for researching autoimmune and autoinflammatory diseases.
CAS Number
2982807-58-7
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
O=C (NC1=CNC=2C=CC (Cl) =CC21) N3CC4=CC=C (C=C4CC3) C=5C=CC (OC) =CC5
Molecular Formula
C25H22ClN3O2
Molecular Weight
431.91
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(5-chloro-1H-indol-3-yl)-6-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
CAS Number2982807-58-7
PubChem CID175935378
IUPAC NameN-(5-chloro-1H-indol-3-yl)-6-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
Molecular FormulaC25H22ClN3O2
Molecular Weight431.9
XLogP5
Topological Polar Surface Area57.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity626
SMILES
COC1=CC=C(C=C1)C2=CC3=C(CN(CC3)C(=O)NC4=CNC5=C4C=C(C=C5)Cl)C=C2
InChI
InChI=1S/C25H22ClN3O2/c1-31-21-7-4-16(5-8-21)17-2-3-19-15-29(11-10-18(19)12-17)25(30)28-24-14-27-23-9-6-20(26)13-22(23)24/h2-9,12-14,27H,10-11,15H2,1H3,(H,28,30)
InChIKey
AUSYUSVLGAIDPV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(5-chloro-1H-indol-3-yl)-6-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
CAS: 2982807-58-7
CID: 175935378
Formula: C25H22ClN3O2
MW: 431.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.9
XLogP35
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass431.1400546
Monoisotopic Mass431.1400546
Topological Polar Surface Area57.4 Ų
Heavy Atom Count31
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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