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PVTX-405

CAT: 0013-GTR19263629-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263629-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 μM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.
CAS Number
2991021-08-8
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
C (N1CCC2 (C=3C (OC2) =C4C (=CC3) C (=O) N (C4) [C@@H]5C (=O) NC (=O) CC5) CC1) C6=CC (=CC=C6) C7=CN (C) N=C7
Molecular Formula
C30H31N5O4
Molecular Weight
525.60
Storage Conditions
-20°C
Notes
For research use only.

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