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CFON-026

CAT: 0013-GTR19263590-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263590-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CFON-026 is a selective, orally active, non-covalent BTK inhibitor with an IC50 of 0.27 nM. It demonstrates significant antitumor activity against wild-type BTK (TMD8 and REC-1) as well as all clinically relevant BTK resistance mutations (BTKC481S, T474I, L528W, and V416L) . CFON-026 induces complete tumor regression in the TMD8 xenograft mouse model. This compound is applicable for research into hematologic cancers, such as chronic lymphocytic leukemia and Waldenström's macroglobulinemia.
CAS Number
2941611-57-8
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
NC=1C=2N3C ([C@]4 (C[C@] (NC (=O) CCCCC\C=C\C3=CN1) (CCC4) [H]) [H]) =NC2C5=CC=C (C (NC6=CC (C#N) =CC=N6) =O) C=C5
Molecular Formula
C33H34N8O2
Molecular Weight
574.68
Storage Conditions
-20°C
Notes
For research use only.

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