KD-026

CAT: 0013-GTR19174607-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19174607-01Size:1 mg

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Description

KD-026 (SLx-4090) is a potent and selective microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. This small molecule is utilized in preclinical research for type 2 diabetes, investigating mechanisms related to lipid metabolism and chylomicron production in both in vitro and in vivo models.

CAS Number

913541-47-6

Product Name Alternative

Inhibitor, enterocytic-specific, inhibit, MTP inhibitor, MTP, KD026, KD-026, KD 026, microsomal triglyceride transfer protein, dyslipidemia, SLx4090, SLx-4090, SLx 4090

Field of Research

Metabolism Research, Protein Biochemistry

Purity

99.73% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.66 mM) ; DMSO:55 mg/mL (100.63 mM)

Smiles

COc1cccc (C (=O) Nc2ccc3CN (CCc3c2) C (=O) Oc2ccccc2) c1-c1ccc (cc1) C (F) (F) F

Molecular Formula

C31H25F3N2O4

Molecular Weight

546.54

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Slx-4090

SLx-4090 is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes.

CAS Number	913541-47-6
PubChem CID	53497429
IUPAC Name	phenyl 6-[[3-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxylate
Molecular Formula	C31H25F3N2O4
Molecular Weight	546.5
XLogP	6.5
Topological Polar Surface Area	67.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	40
Formal Charge	0
Complexity	856

SMILES

COC1=CC=CC(=C1C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=CC4=C(CN(CC4)C(=O)OC5=CC=CC=C5)C=C3

InChI

InChI=1S/C31H25F3N2O4/c1-39-27-9-5-8-26(28(27)20-10-13-23(14-11-20)31(32,33)34)29(37)35-24-15-12-22-19-36(17-16-21(22)18-24)30(38)40-25-6-3-2-4-7-25/h2-15,18H,16-17,19H2,1H3,(H,35,37)

InChIKey

AZUIUVJESCFSLJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 913541-47-6

CID: 53497429

Formula: C31H25F3N2O4

MW: 546.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	546.5
XLogP3	6.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	546.17664177
Monoisotopic Mass	546.17664177
Topological Polar Surface Area	67.9 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	856
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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KD-026

Chemical Information

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