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AR antagonist 15

CAT: 0013-GTR19263499-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263499-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR antagonist 15 is an orally active androgen receptor (AR) antagonist with an IC50 of 97 nM for ART787A. It impairs AR nuclear translocation, hinders AR homodimerization, and inhibits AR-regulated gene transcription by competitively binding to the ligand-binding pocket. AR antagonist 15 significantly reduces prostate-specific antigen (PSA) levels and induces apoptosis by decreasing the expression of apoptosis-related proteins. This compound is useful for prostate cancer research.
CAS Number
1790308-86-9
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=S (=O) (NC1=CC=C (OCC=2C=CC=CC2) C=C1) N3CCCCC3
Molecular Formula
C18H22N2O3S
Molecular Weight
346.44
Storage Conditions
-20°C
Notes
For research use only.

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