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FGFR2/3-IN-3

CAT: 0013-GTR19263491-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263491-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50 values of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), displaying efficacy against both wild-type and mutant FGFR3. It exhibits low CYP3A4 inhibition and minimal hERG toxicity. By inhibiting mutant FGFR3-mediated pathways, FGFR2/3-IN-3 improves chondrocyte proliferation and differentiation imbalances, promoting bone growth. In a dwarfism mouse model, it demonstrates growth-promoting effects, indicating potential for treating bone development disorders such as achondroplasia (ACH) .
CAS Number
3069945-78-1
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction
Smiles
O ([C@H] (C) C=1C (Cl) =CN=CC1Cl) C=2C=C3C (=NNC3=CC2C) C=4C=C (F) C (=NC4) C5=CN (CC (C) (C) O) N=C5C
Molecular Formula
C28H27Cl2FN6O2
Molecular Weight
569.46
Storage Conditions
-20°C
Notes
For research use only.

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