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PTC-700

CAT: 0013-GTR19263317-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263317-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTC-700 is an effective splicing modulator of microtubule-associated protein tau (MAPT) . It reduces 4R MAPT in P301L and S305N neurons with EC50 values of 1.3 to 1.8 nM and 0.5 to 2.6 nM, respectively.
CAS Number
2476726-76-6
Field of Research
Signal Transduction
Smiles
N (CC1=NC=CS1) C2=C3C (C (C) =C (C[C@H] (C) N) S3) =NC (Cl) =C2
Molecular Formula
C15H17ClN4S2
Molecular Weight
352.91
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-[(2S)-2-aminopropyl]-5-chloro-3-methyl-N-(1,3-thiazol-2-ylmethyl)thieno[3,2-b]pyridin-7-amine
CAS Number2476726-76-6
PubChem CID155066294
IUPAC Name2-[(2S)-2-aminopropyl]-5-chloro-3-methyl-N-(1,3-thiazol-2-ylmethyl)thieno[3,2-b]pyridin-7-amine
Molecular FormulaC15H17ClN4S2
Molecular Weight352.9
XLogP3.6
Topological Polar Surface Area120
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count22
Formal Charge0
Complexity375
SMILES
CC1=C(SC2=C1N=C(C=C2NCC3=NC=CS3)Cl)C[C@H](C)N
InChI
InChI=1S/C15H17ClN4S2/c1-8(17)5-11-9(2)14-15(22-11)10(6-12(16)20-14)19-7-13-18-3-4-21-13/h3-4,6,8H,5,7,17H2,1-2H3,(H,19,20)/t8-/m0/s1
InChIKey
MQOINCWBWZFTAY-QMMMGPOBSA-N
Chemical Structure
2D Structure
2D structure of 2-[(2S)-2-aminopropyl]-5-chloro-3-methyl-N-(1,3-thiazol-2-ylmethyl)thieno[3,2-b]pyridin-7-amine
CAS: 2476726-76-6
CID: 155066294
Formula: C15H17ClN4S2
MW: 352.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.9
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass352.0583166
Monoisotopic Mass352.0583166
Topological Polar Surface Area120 Ų
Heavy Atom Count22
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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