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AF-45

CAT: 0931-T210271-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T210271-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
IRAK|||NF-?B|||p38 MAPK|||TNF
Related Pathways
NF-?B|||Immunology/Inflammation|||MAPK|||Apoptosis
Bioactivity
AF-45 inhibits IRAK4 and IRAK1 with IC50 values of 128 nM and 1765 nM, respectively. It suppresses the release of IL-6 and TNF-? in macrophages, with IC50 ranges of 0.53-1.54 ?M and 0.6-2.75 ?M, respectively. Additionally, AF-45 acts as an inhibitor of the NF-?B/MAPK signaling pathway. In mouse models, AF-45 exhibits anti-inflammatory activity against DSS-induced ulcerative colitis and lipopolysaccharide-induced acute lung injury. In rat models, AF-45 demonstrates favorable pharmacokinetic properties.
Molecular Formula
C22H25N3O3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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