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Isoniazid-d4

CAT: 0804-HY-B0329S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0329S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].
CAS Number
774596-24-6
Product Name Alternative
INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Autophagy; Bacterial; Mitophagy
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy
Field of Research
Infection
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 33.33mg/mL (ultrasonic)
Smiles
NNC(C1=C([2H])C([2H])=NC([2H])=C1[2H])=O
Molecular Formula
C6H3D4N3O
Molecular Weight
141.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG) . J Biol Chem, 2009. 284 (11) : p. 7017-29.|[3]Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48 (8) : p. 3006-9.|[4]Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322 (5906) : p. 1392-5.|[5]Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200 (7) : p. 1136-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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