Isoniazid

CAT: 0804-HY-B0329-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0329-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].
CAS Number
[54-85-3]
Product Name Alternative
INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Autophagy; Bacterial; Mitophagy
Type
Reference compound
Related Pathways
Anti-infection; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Isoniazid.html
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC=C1)NN
Molecular Formula
C6H7N3O
Molecular Weight
137.14
Precautions
H302
References & Citations
[1]Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG) . J Biol Chem, 2009. 284 (11) : p. 7017-29.|[2]Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48 (8) : p. 3006-9.|[3]Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322 (5906) : p. 1392-5.|[4]Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200 (7) : p. 1136-43.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

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