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EN1441

CAT: 0013-GTR19258117-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258117-02Size:10 mg
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Description
EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.
CAS Number
2196448-47-0
Field of Research
Metabolism Research
Smiles
O=C (C=C) N1C2=CC (Cl) =CC=C2NC (=O) C1 (C) C
Molecular Formula
C13H13ClN2O2
Molecular Weight
264.708
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-Chloro-3,3-dimethyl-4-(prop-2-enoyl)-1,2,3,4-tetrahydroquinoxalin-2-one
CAS Number2196448-47-0
PubChem CID132317790
IUPAC Name6-chloro-3,3-dimethyl-4-prop-2-enoyl-1H-quinoxalin-2-one
Molecular FormulaC13H13ClN2O2
Molecular Weight264.71
XLogP2.1
Topological Polar Surface Area49.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity394
SMILES
CC1(C(=O)NC2=C(N1C(=O)C=C)C=C(C=C2)Cl)C
InChI
InChI=1S/C13H13ClN2O2/c1-4-11(17)16-10-7-8(14)5-6-9(10)15-12(18)13(16,2)3/h4-7H,1H2,2-3H3,(H,15,18)
InChIKey
RSKGPRCITYZGEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-Chloro-3,3-dimethyl-4-(prop-2-enoyl)-1,2,3,4-tetrahydroquinoxalin-2-one
CAS: 2196448-47-0
CID: 132317790
Formula: C13H13ClN2O2
MW: 264.71
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.71
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass264.0665554
Monoisotopic Mass264.0665554
Topological Polar Surface Area49.4 Ų
Heavy Atom Count18
Formal Charge0
Complexity394
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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