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EN171

CAT: 0013-GTR19238966-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238966-01Size:25 mg
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Description
EN171 is a covalent molecular glue that selectively targets 14-3-3 proteins, enhancing their interactions with client proteins like ERα, YAP, and TAZ to disrupt oncogenic transcriptional pathways. It also serves as a recruiter in heterobifunctional molecules for the cytosolic sequestration of nuclear targets such as BRD4, applicable in cancer research and targeted protein degradation studies.
CAS Number
2191110-79-7
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Smiles
O=C (C=C) N1CCC2 (C1) CN (CC=3C=CC=CC3) CC2
Molecular Formula
C17H22N2O
Molecular Weight
270.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-{7-Benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one
CAS Number2191110-79-7
PubChem CID132317810
IUPAC Name1-(7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one
Molecular FormulaC17H22N2O
Molecular Weight270.37
XLogP2.2
Topological Polar Surface Area23.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity375
SMILES
C=CC(=O)N1CCC2(C1)CCN(C2)CC3=CC=CC=C3
InChI
InChI=1S/C17H22N2O/c1-2-16(20)19-11-9-17(14-19)8-10-18(13-17)12-15-6-4-3-5-7-15/h2-7H,1,8-14H2
InChIKey
VKQVCQHCQMFBNJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-{7-Benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one
CAS: 2191110-79-7
CID: 132317810
Formula: C17H22N2O
MW: 270.37
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight270.37
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass270.173213330
Monoisotopic Mass270.173213330
Topological Polar Surface Area23.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-W1005067-01EN171

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