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Antifibrotic agent 1

CAT: 0013-GTR19257988-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257988-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antifibrotic agent 1 is an orally active medication designed to treat idiopathic pulmonary fibrosis (IPF) . It effectively mitigates IPF-related processes, including TGF-β-induced epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT), as well as profibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α, and Src family kinases (SFKs), while sparing VEGFR, FGFR, and Abl to minimize off-target toxicity. In a bleomycin (BLM) -induced pulmonary fibrosis mouse model, it demonstrates strong antifibrotic activity.
Field of Research
Cardiovascular Research, Signal Transduction
Molecular Formula
C27H23ClN6O2
Storage Conditions
-20°C
Notes
For research use only.

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