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AS-605240 potassium

CAT: 0013-GTR19257975-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257975-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 μM and 0.550 μM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.
Field of Research
Signal Transduction
Molecular Formula
C12H6KN3O2S
Storage Conditions
-20°C
Notes
For research use only.

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