AS-605240 potassium

CAT: 0931-T207195-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207195-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PI3K, Akt

Related Pathways

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling

Bioactivity

AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 μM and 0.550 μM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.

Molecular Formula

C12H6KN3O2S

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19257975-01	AS-605240 potassium
HY-10109A	AS-605240 (potassium)
A5176-50	AS-605240
MBS130003-01	AS 605240

AS-605240 potassium

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