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CHMFL-FLT3-122

CAT: 0013-GTR19257539-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257539-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (50 mg/kg) without exhibiting obvious toxicity in vivo.
CAS Number
1839150-56-9
Product Name Alternative
FLT3 (ITD), CHMFL FLT3 122, CHMFLFLT 3122, CHMFLFLT3122, CHMFL-FLT3-122, CHMFLFLT-3122
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.56% (May vary between batches)
Solubility
DMSO:90 mg/mL (190.86 mM) ;1eq. HCl:90 mg/mL (190.86 mM)
Smiles
NC1=C2C (N (N=C2C3=CC=C (OC4=CC=CC=C4) C=C3) [C@H]5CN (C (CN (C) C) =O) CCC5) =NC=N1
Molecular Formula
C26H29N7O2
Molecular Weight
471.55
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Chmfl-flt3-122
CAS Number1839150-56-9
PubChem CID121513893
IUPAC Name1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
Molecular FormulaC26H29N7O2
Molecular Weight471.6
XLogP3.1
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity695
SMILES
CN(C)CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
InChI
InChI=1S/C26H29N7O2/c1-31(2)16-22(34)32-14-6-7-19(15-32)33-26-23(25(27)28-17-29-26)24(30-33)18-10-12-21(13-11-18)35-20-8-4-3-5-9-20/h3-5,8-13,17,19H,6-7,14-16H2,1-2H3,(H2,27,28,29)/t19-/m1/s1
InChIKey
IZNAFSDUTMZGSF-LJQANCHMSA-N
Chemical Structure
2D Structure
2D structure of Chmfl-flt3-122
CAS: 1839150-56-9
CID: 121513893
Formula: C26H29N7O2
MW: 471.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.6
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass471.23827319
Monoisotopic Mass471.23827319
Topological Polar Surface Area102 Ų
Heavy Atom Count35
Formal Charge0
Complexity695
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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