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CHMFL-EGFR-202

CAT: 0013-GTR19216953-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216953-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases) . (In Vitro) :CHMFL-EGFR-202 exhibits ~10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 potently inhibits EGFR primary mutants (L858R, del19) and drug-resistant mutant L858R/T790M. CHMFL-EGFR-202 displays strong binding affinities against wild-type, L861Q, G719C/S, L858R/T790M, L858R, and T790M among EGFR wild-type and mutant kinases. CHMFL-EGFR-202 also exhibits strong binding affinities against BLK, BMX, BTK, ERBB2, ERBB4, LOK, MEK1, and MEK5 kinases (percent of control score less than 1% at 1 μM) . CHMFL-EGFR-202 strongly inhibits BLK, BTK, ERBB2 and ERBB4 (IC50s: of 8.1 nM, 24.5 nM, 8.1 nM and 3.2 nM) . CHMFL-EGFR-202 moderately inhibits BMX and MEK1 kinases (IC50s: 111.0 nM and 161.0 nM) .
CAS Number
2089381-40-6
Field of Research
Cell Biology
Purity
>98% (HPLC)
Smiles
Nc1ncnc2n (nc (-c3ccc (OCc4ccccn4) c (Cl) c3) c12) [C@@H]1CCCN (C1) C (=O) C=C
Molecular Formula
C25H24ClN7O2
Molecular Weight
489.96
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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BA6389-1CHMFL-EGFR-202
A12524-100CHMFL-EGFR-202 100mg
A12524-10CHMFL-EGFR-202 10mg
A12524-5CHMFL-EGFR-202 5mg
A12524-1CHMFL-EGFR-202 1mg
A12524-25CHMFL-EGFR-202 25mg
A12524-2CHMFL-EGFR-202 2mg
A12524-50CHMFL-EGFR-202 50mg
A12524-10mM-DCHMFL-EGFR-202 10mM * 1mL in DMSO
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