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Kylo-0603

CAT: 0013-GTR19258087-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258087-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KYLO-0603 is an orally active and selective THR-β agonist with an EC50 of 31.07 nM. It effectively reduces serum cholesterol and low-density lipoprotein cholesterol levels. By activating THR-β receptors, KYLO-0603 enhances the expression of THR-regulated genes like iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone-responsive (Thrsp) gene, while it inhibits the expression of inflammatory and fibrosis-related genes, including low-density lipoprotein receptor (LDL-R) gene. This compound is applicable for the study of metabolic associated steatohepatitis (MASH) and liver fibrosis.
CAS Number
2661053-09-2
Field of Research
Immunology & Inflammation, Metabolism Research
Smiles
C (NC (CCCCCNC (COC1=CC (C) =C (CC2=CC (C (C) C) =C (O) C=C2) C (C) =C1) =O) =O) (COCCC (NCCCCCCO[C@H]3[C@H] (NC (C) =O) [C@@H] (O) [C@@H] (O) [C@@H] (CO) O3) =O) (COCCC (NCCCCCCO[C@H]4[C@H] (NC (C) =O) [C@@H] (O) [C@@H] (O) [C@@H] (CO) O4) =O) COCCC (NCCCCCCO[C@H]5[C@H] (NC (C) =O) [C@@H] (O) [C@@H] (O) [C@@H] (CO) O5) =O
Molecular Formula
C81H134N8O28
Molecular Weight
1667.97
Storage Conditions
-20°C
Notes
For research use only.

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