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Boc-PEG2-Val-Cit-PAB-OH

CAT: 0013-GTR19254323-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19254323-01Size:10 mg
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Description
Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.
CAS Number
2055024-55-8
Field of Research
Metabolism Research
Smiles
[C@H] (C (NC1=CC=C (CO) C=C1) =O) (NC ([C@@H] (NC (CCOCCOCCNC (OC (C) (C) C) =O) =O) [C@H] (C) C) =O) CCCNC (N) =O
Molecular Formula
C30H50N6O9
Molecular Weight
638.753
Storage Conditions
-20°C
Notes
For research use only.

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