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Boc-PEG2-Val-Cit-PAB-OH

CAT: 0931-TYD-01991-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TYD-01991-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2055024-55-8
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.
Smiles
[C@H](C(NC1=CC=C(CO)C=C1)=O)(NC([C@@H](NC(CCOCCOCCNC(OC(C)(C)C)=O)=O)[C@H](C)C)=O)CCCNC(N)=O
Molecular Formula
C30H50N6O9
Molecular Weight
638.753
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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