SARS-CoV-2 Mpro-IN-29

SARS-CoV-2 Mpro-IN-29

• UNSPSC Description: SARS-CoV-2 Mpro-IN-29 (Compound 7) is an inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 310 nM and an EC50 of 0.5 μM in Vero cells. SARS-CoV-2 Mpro-IN-29 binds to the active site of Mpro, blocking the cleavage of viral polyproteins, showing significant antiviral activity and enhanced metabolic function. SARS-CoV-2 Mpro-IN-29 holds potential for research on SARS-CoV-2 antiviral agents[1].
• Target Antigen: SARS-CoV; Virus Protease
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-mpro-in-29.html
• Smiles: O=C([C@@H](NC(C1=CC2=C(C=CC=C2OC)N1)=O)CC(C)C)N[C@@H](CC3=CSC=N3)C(S(=O)(O[Na])=O)(O)[H]
• Molecular Weight: 546.59
• References & Citations: [1]Feys JR, et al. Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease. ACS Med Chem Lett. 2024 Nov 3;15(11):2046-2052.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported