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DP-15

CAT: 0013-GTR19249621-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249621-01Size:10 mg
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Description
DP-15 is a potent bifunctional degrader of GSPT1 and BRD4, demonstrating nanomolar-range DC50 values. It exhibits strong antiproliferative effects, induces G1 arrest and apoptosis in AML cells like MOLM13, and shows in vivo efficacy in xenograft models, supporting its use in oncology research for leukemia and lymphoma studies.
CAS Number
3033837-71-4
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
CC=1C2=C (N3C ([C@H] (CC (=O) N4CCN (CC5CCN (CC5) C=6C=C7C (=CC6) C (=O) N (C7=O) C8C (=O) NC (=O) CC8) CC4) N=C2C9=CC=C (Cl) C=C9) =NN=C3C) SC1C
Molecular Formula
C42H44ClN9O5S
Molecular Weight
822.374
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 171476753
CAS Number3033837-71-4
PubChem CID171476753
IUPAC Name5-[4-[[4-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]piperazin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Molecular FormulaC42H44ClN9O5S
Molecular Weight822.4
XLogP4.1
Topological Polar Surface Area182
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Heavy Atom Count58
Formal Charge0
Complexity1650
SMILES
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)N4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C9=CC=C(C=C9)Cl)C
InChI
InChI=1S/C42H44ClN9O5S/c1-23-24(2)58-42-36(23)37(27-4-6-28(43)7-5-27)44-32(38-47-46-25(3)51(38)42)21-35(54)50-18-16-48(17-19-50)22-26-12-14-49(15-13-26)29-8-9-30-31(20-29)41(57)52(40(30)56)33-10-11-34(53)45-39(33)55/h4-9,20,26,32-33H,10-19,21-22H2,1-3H3,(H,45,53,55)/t32-,33?/m0/s1
InChIKey
NQXAVWUIYCADSJ-JEFWXSHNSA-N
Chemical Structure
2D Structure
2D structure of CID 171476753
CAS: 3033837-71-4
CID: 171476753
Formula: C42H44ClN9O5S
MW: 822.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight822.4
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass821.2874644
Monoisotopic Mass821.2874644
Topological Polar Surface Area182 Ų
Heavy Atom Count58
Formal Charge0
Complexity1650
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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